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Nexium is a welcome treatment for gastroesophagael reflux disease with the acronym GERD. Nexium is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophagael reflux disease, and Zollinger-Ellison syndrome.
This drug has 50 to 90% bioavailability, hepatic metabolism, a half-life of 1-1.5 hours, 80% renal and 20% faecal excretion. It is given through oral admiistration. There are common side effects with this drug that include headache, diarrhea, nausea, gas, loss of appetite, constipation, cotton mouth, and abdominal pain in the stomatch. There are also severe allergic reactions that can occur. There has been some controversy in how AstraZeneca has been marketing the drug that try to get their scientists to claim certain advantages that aren’t there to get a marketing advantage. There are several brand names for Nexium that include Sompraz, Zoleri, Lucen, Esopral, Axagon, and Nexiam. Its technical name is Esomeprazole. There is a large difference between this and other proton pump inhiitors. There is a delayed-release capsule and delayed-release tablet in Australia and Canada in strengths of 20 mg to 40 mg.
These are enteric-coated because there is a rapid degradation of the drug in the acidic conditions of the stomach. Thus, capsules are formulated using the multiple-unit pellet system. These are extremely small enteric-coated granules or pellets wrapped in an outer shell. Common side effects of this drug include headache, diarrhea, gas, constipation, dry mouth, and abdominal pain. There are severe side effects like fever, stomach pain, and bruising. Nexium competes with the enzymes of CYP2C10 and CYP2C9, and it can interact with drugs that use them for metabolism. A drug called Plavix can be reduced in effectiveness by this drug because Plavix requires on one of those enzymes to work. AstraZeneca has been severely reprimanded for how it has created, marketed, and patented the drug.